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In certain embodiments, the chimeric tetracycline repressors of the present invention comprise an amino-terminal DNA-binding domain and a carboxy-terminal tetracycline binding domain, including but not limited to the corresponding domains of the TetR(A), TetR(B), TetR(C), TetR(D), TetR(E), TetR(G), TetR(H), TetR(J), and TetR(Z). Be sure to know what effect it has on you at home before you plan to take it daily and drive a car?